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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731442
Species: Mus musculus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp12decreases expressionEXP 6480464CTDmethylmercuric chloride results in decreased expression of CASP12 proteinPMID:31330229
Casp12multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of CASP12 protein]; DDIT3 protein promotes the reaction [methylmercuric chloride results in decreased expression of CASP12 protein]; HSP90B1 protein promotes the reaction [methylmercuric chloride results in decreased expression of CASP12 protein]; HSPA5 protein promotes the reaction [methylmercuric chloride results in decreased expression of CASP12 protein]; XBP1 protein promotes the reaction [methylmercuric chloride results in decreased expression of CASP12 protein]PMID:31330229
Casp12multiple interactionsISOCasp12 (Rattus norvegicus)6480464CTD[Hydrocarbons, Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in increased expression of CASP12 mRNAPMID:30744511
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