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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737316
Species: Homo sapiens
RGD Object: Gene
Symbol: CBS
Name: cystathionine beta-synthase
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CBSincreases expressionEXP 6480464CTDRotenone results in increased expression of CBS mRNAPMID:24810058
CBSdecreases expressionISOCbs (Mus musculus)6480464CTDRotenone results in decreased expression of CBS mRNA; Rotenone results in decreased expression of CBS proteinPMID:25086357
CBSmultiple interactionsISOCbs (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Rotenone results in decreased expression of CBS protein]; CBS protein inhibits the reaction [Rotenone results in decreased expression of IL10 mRNA]; CBS protein inhibits the reaction [Rotenone results in increased abundance of Dinoprostone]; CBS protein inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]; CBS protein inhibits the reaction [Rotenone results in increased expression of TNF mRNA]PMID:25086357
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