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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621315
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map1lc3b
Name: microtubule-associated protein 1 light chain 3 beta
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map1lc3bdecreases lipidationEXP 6480464CTDRotenone results in decreased lipidation of MAP1LC3B proteinPMID:35104487
Map1lc3bincreases expressionEXP 6480464CTDRotenone results in increased expression of MAP1LC3B mRNAPMID:28374803
Map1lc3bmultiple interactionsEXP 6480464CTDChloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased lipidation of MAP1LC3B protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased lipidation of MAP1LC3B protein]PMID:35104487
Map1lc3bdecreases expressionISOMap1lc3b (Mus musculus)6480464CTDRotenone results in decreased expression of MAP1LC3B mRNAPMID:23186747
Map1lc3bincreases expressionISOMap1lc3b (Mus musculus)6480464CTDRotenone results in increased expression of MAP1LC3B proteinPMID:26847702
Map1lc3bincreases lipidationISOMAP1LC3B (Homo sapiens)6480464CTDRotenone results in increased lipidation of MAP1LC3B proteinPMID:31648047 PMID:37156403
Map1lc3bmultiple interactionsISOMAP1LC3B (Homo sapiens)6480464CTD4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Rotenone results in increased lipidation of MAP1LC3B protein]; [Rotenone co-treated with bafilomycin B1] results in increased lipidation of and results in increased cleavage of MAP1LC3B protein; ATP6V0D1 protein affects the reaction [Rifampin inhibits the reaction [Rotenone results in increased lipidation of MAP1LC3B protein]]; CSNK2A1 protein affects the reaction [Rotenone results in increased lipidation of MAP1LC3B protein]; Decitabine inhibits the reaction [Rotenone results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]; PGAM5 protein affects the reaction [Rotenone results in increased lipidation of MAP1LC3B protein]; Rifampin inhibits the reaction [Rotenone results in increased lipidation of MAP1LC3B protein]; Rotenone affects the lipidation of and affects the cleavage of MAP1LC3B proteinPMID:30673822 PMID:31648047 PMID:37156403
Map1lc3bmultiple interactionsISOMap1lc3b (Mus musculus)6480464CTDwortmannin inhibits the reaction [Rotenone results in increased expression of MAP1LC3B protein]PMID:26847702
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