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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3715
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a3
Name: solute carrier family 6 member 3
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a3decreases expressionEXP 6480464CTDRotenone results in decreased expression of SLC6A3 mRNA; Rotenone results in decreased expression of SLC6A3 proteinPMID:18289173 PMID:32481507
Slc6a3increases expressionEXP 6480464CTDRotenone results in increased expression of SLC6A3 proteinPMID:18579341 PMID:23567316
Slc6a3multiple interactionsEXP 6480464CTDlipopolysaccharide, E coli O55-B5 promotes the reaction [Rotenone results in increased expression of SLC6A3 protein]; Melatonin inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein]; Nomifensine inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein]; Rotenone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SLC6A3 protein]PMID:18289173 PMID:23567316
Slc6a3decreases expressionISOSLC6A3 (Homo sapiens)6480464CTDRotenone results in decreased expression of SLC6A3 mRNAPMID:29955902 PMID:33512557
Slc6a3increases response to substanceISOSLC6A3 (Homo sapiens)6480464CTDSLC6A3 protein results in increased susceptibility to RotenonePMID:18206288
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