Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3227
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Odc1
Name: ornithine decarboxylase 1
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Odc1increases expressionEXP 6480464CTDRotenone results in increased expression of ODC1 mRNAPMID:27900601
Odc1decreases expressionISOOdc1 (Mus musculus)6480464CTDRotenone results in decreased expression of ODC1 mRNAPMID:22016648
Odc1increases activityISOODC1 (Homo sapiens)6480464CTDRotenone results in increased activity of ODC1 proteinPMID:9834970
Odc1multiple interactionsISOOdc1 (Mus musculus)6480464CTDRotenone analog inhibits the reaction [MYC protein results in increased activity of ODC1 protein]PMID:9270009
Odc1multiple interactionsISOODC1 (Homo sapiens)6480464CTDRotenone inhibits the reaction [Estradiol results in increased activity of ODC1 protein]; Rotenone inhibits the reaction [IGF1 protein results in increased activity of ODC1 protein]; Rotenone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]PMID:9834970
Go Back to source page   Continue to Ontology report