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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353141
Species: Homo sapiens
RGD Object: Gene
Symbol: LRRK2
Name: leucine rich repeat kinase 2
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LRRK2decreases response to substanceEXP 6480464CTDLRRK2 protein results in decreased susceptibility to RotenonePMID:19625511 PMID:20067578
LRRK2increases response to substanceEXP 6480464CTDLRRK2 gene polymorphism results in increased susceptibility to Rotenone; LRRK2 protein results in increased susceptibility to RotenonePMID:19692353 PMID:19741132
LRRK2multiple interactionsEXP 6480464CTDPMK-1 protein affects the reaction [LRRK2 protein results in decreased susceptibility to Rotenone]; PRKN protein inhibits the reaction [LRRK2 gene polymorphism results in increased susceptibility to Rotenone]; SEK-1 protein affects the reaction [LRRK2 protein results in decreased susceptibility to Rotenone]PMID:19741132 PMID:20067578
LRRK2affects expressionISOLrrk2 (Rattus norvegicus)6480464CTDRotenone affects the expression of LRRK2 mRNAPMID:31814881
LRRK2increases expressionISOLrrk2 (Mus musculus)6480464CTDRotenone results in increased expression of LRRK2 mRNAPMID:30207190
LRRK2multiple interactionsISOLrrk2 (Mus musculus)6480464CTD[Rotenone co-treated with Luteolin] results in increased expression of LRRK2 mRNA; Luteolin inhibits the reaction [Rotenone results in increased expression of LRRK2 mRNA]PMID:30207190
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