Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1351472
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	ADIPOQ
Name:	adiponectin, C1Q and collagen domain containing

Acc ID:	CHEBI:28201
Term:	rotenone
Definition:	A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID:	MESH:D012402

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
ADIPOQ	decreases expression	ISO	Adipoq (Rattus norvegicus)	6480464	CTD	Rotenone results in decreased expression of ADIPOQ protein	PMID:33137417
ADIPOQ	multiple interactions	ISO	Adipoq (Rattus norvegicus)	6480464	CTD	7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Rotenone results in decreased expression of ADIPOQ protein]; ADIPOQ protein inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; ADIPOQ protein inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]; ADIPOQ protein inhibits the reaction [Rotenone results in increased expression of SQSTM1 protein]; ADIPOQ protein inhibits the reaction [Rotenone results in increased phosphorylation of EIF2AK3 protein]; ADIPOQ protein inhibits the reaction [Rotenone results in increased phosphorylation of EIF2S1 protein]; ADIPOQ protein promotes the reaction [Rotenone results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Rotenone results in increased expression of SQSTM1 protein]]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Rotenone results in increased phosphorylation of EIF2AK3 protein]]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Rotenone results in increased phosphorylation of EIF2S1 protein]]; dorsomorphin inhibits the reaction [ADIPOQ protein promotes the reaction [Rotenone results in decreased phosphorylation of MTOR protein]]	PMID:33137417

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