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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347965
Species: Homo sapiens
RGD Object: Gene
Symbol: TUBB3
Name: tubulin beta 3 class III
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TUBB3decreases expressionEXP 6480464CTDRotenone results in decreased expression of TUBB3 mRNAPMID:33512557
TUBB3affects expressionISOTubb3 (Mus musculus)6480464CTDRotenone affects the expression of TUBB3 mRNAPMID:21893155
TUBB3decreases expressionISOTubb3 (Mus musculus)6480464CTDRotenone results in decreased expression of TUBB3 proteinPMID:35919817
TUBB3multiple interactionsISOTubb3 (Mus musculus)6480464CTDTRP53 affects the reaction [Rotenone affects the expression of TUBB3 mRNA]PMID:21893155
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