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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304628
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Exog
Name: exo/endonuclease G
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Exogmultiple interactionsEXP 6480464CTD[EXOG protein co-treated with Rotenone] results in decreased expression of PPARGC1A mRNA; [EXOG protein co-treated with Rotenone] results in decreased expression of PPARGC1A protein; [EXOG protein co-treated with Rotenone] results in decreased expression of SSBP1 protein; EXOG protein inhibits the reaction [Rotenone results in decreased expression of HSF1 protein]; EXOG protein inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]; EXOG protein inhibits the reaction [Rotenone results in decreased expression of TFAM protein]; EXOG protein inhibits the reaction [Rotenone results in decreased expression of TH protein]; Rotenone affects the expression of and affects the localization of EXOG protein; ZLN005 affects the reaction [Rotenone affects the expression of EXOG protein]PMID:33515431
Exogincreases expressionISOExog (Mus musculus)6480464CTDRotenone results in increased expression of EXOG mRNAPMID:32937126
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