Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11300
Species: Mus musculus
RGD Object: Gene
Symbol: Slc18a2
Name: solute carrier family 18 (vesicular monoamine), member 2
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc18a2decreases activityISOSLC18A2 (Homo sapiens)6480464CTDRotenone results in decreased activity of SLC18A2 proteinPMID:25496994
Slc18a2decreases expressionISOSlc18a2 (Rattus norvegicus)6480464CTDRotenone results in decreased expression of SLC18A2 mRNA; Rotenone results in decreased expression of SLC18A2 proteinPMID:18579341 PMID:26276080 PMID:28238857 PMID:28585189
Slc18a2multiple interactionsISOSlc18a2 (Rattus norvegicus)6480464CTDasiaticoside inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA]; Dabigatran inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of SLC18A2 protein]PMID:26276080 PMID:28238857 PMID:28585189
Slc18a2multiple interactionsISOSLC18A2 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [Rotenone results in decreased activity of SLC18A2 protein]PMID:25496994
Go Back to source page   Continue to Ontology report