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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:28179
Term: benzamide
Definition: An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.
Chemical ID: MESH:C037689
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1decreases activityEXP 6480464CTDbenzamide results in decreased activity of PARP1 proteinPMID:12411406
Parp1decreases activityISOPARP1 (Homo sapiens)6480464CTDbenzamide results in decreased activity of PARP1 proteinPMID:17669606 PMID:18695944
Parp1decreases activityISOParp1 (Mus musculus)6480464CTDbenzamide results in decreased activity of PARP1 proteinPMID:11593040
Parp1decreases expressionISOParp1 (Mus musculus)6480464CTDbenzamide results in decreased expression of PARP1 proteinPMID:19998477
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD[benzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [benzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]; benzamide inhibits the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]; benzamide inhibits the reaction [PARP1 protein binds to MOR enhancer mutant form]; benzamide inhibits the reaction [TNF protein promotes the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]]PMID:17669606 PMID:19447888
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTD[benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Hydrogen Peroxide; [benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Methylnitronitrosoguanidine; benzamide inhibits the reaction [[Hydrogen Peroxide results in increased activity of PARP1 protein] which results in decreased abundance of NAD]; benzamide inhibits the reaction [[Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD]PMID:11593040
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