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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:28177
Term: theophylline
Definition: A dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea.
Chemical ID: MESH:D013806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDTheophylline results in decreased expression of BCL2 mRNA; Theophylline results in decreased expression of BCL2 proteinPMID:10877050 PMID:10891529 PMID:15313391 PMID:8822937 PMID:9312165
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Theophylline co-treated with Cisplatin] results in decreased expression of BCL2 protein; [Theophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein; IL4 protein inhibits the reaction [Theophylline results in decreased expression of BCL2 protein]PMID:10891529 PMID:15645133 PMID:8822937
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