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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2980
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kng2
Name: kininogen 2
Acc ID: CHEBI:28158
Term: 6-oxoprostaglandin F1alpha
Definition: A prostaglandin Falpha that is prostaglandin F1alpha bearing a keto substituent at the 6-position.
Chemical ID: MESH:D015121
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kng2increases abundanceEXP 6480464CTDKNG1 protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alphaPMID:4030047
Kng2multiple interactionsEXP 6480464CTD[KNG1 protein modified form binds to and results in increased activity of BDKRB2 protein] which results in increased secretion of 6-Ketoprostaglandin F1 alpha; Dexamethasone inhibits the reaction [KNG1 protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha]PMID:29775649 PMID:4030047
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