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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732502
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:2814
Term: arecoline
Definition: A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Chemical ID: MESH:D001115
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK1increases phosphorylationEXP 6480464CTDArecoline results in increased phosphorylation of MAPK1 proteinPMID:32441858
MAPK1multiple interactionsEXP 6480464CTDU 0126 inhibits the reaction [Arecoline results in increased phosphorylation of MAPK1 protein]PMID:32441858
MAPK1increases phosphorylationISOMapk1 (Rattus norvegicus)6480464CTDArecoline results in increased phosphorylation of MAPK1 proteinPMID:34999050
MAPK1multiple interactionsISOMapk1 (Mus musculus)6480464CTD[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein; Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein]PMID:26464283
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