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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 13903538
Species: Sus scrofa
RGD Object: Gene
Symbol: SERPINE1
Name: serpin family E member 1
Acc ID: CHEBI:2814
Term: arecoline
Definition: A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Chemical ID: MESH:D001115
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SERPINE1increases expressionEXP 6480464CTDArecoline results in increased expression of SERPINE1 proteinPMID:26908192
SERPINE1multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [Arecoline results in increased expression of SERPINE1 protein]PMID:26908192
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