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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620064
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chd4
Name: chromodomain helicase DNA binding protein 4
Acc ID: CHEBI:28121
Term: harmine
Definition: A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7.
Chemical ID: MESH:D006247
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chd4increases phosphorylationISOChd4 (Mus musculus)6480464CTDHarmine results in increased phosphorylation of CHD4 proteinPMID:27805061
Chd4multiple interactionsISOChd4 (Mus musculus)6480464CTDAZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]PMID:27805061
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