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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10495
Species: Mus musculus
RGD Object: Gene
Symbol: Dyrk1a
Name: dual-specificity tyrosine phosphorylation regulated kinase 1a
Acc ID: CHEBI:28121
Term: harmine
Definition: A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7.
Chemical ID: MESH:D006247
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dyrk1adecreases expression ISODyrk1a (Rattus norvegicus)11097969RGDharmine decreases expression of dyrk1a protein after myocardial infarction in rat heart left ventricle 
Dyrk1aaffects bindingISODYRK1A (Homo sapiens)6480464CTDHarmine binds to DYRK1A proteinPMID:25751815
Dyrk1adecreases activityISODYRK1A (Homo sapiens)6480464CTDHarmine results in decreased activity of DYRK1A proteinPMID:21573099
Dyrk1amultiple interactionsISODYRK1A (Homo sapiens)6480464CTDHarmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]PMID:21573099
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