GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NOTCH1 | decreases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of NOTCH1 mRNA | PMID:19684285 | NOTCH1 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of NOTCH1 mRNA | PMID:19684285 | NOTCH1 | multiple interactions | EXP | | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of NOTCH1 mRNA | PMID:29704546 | NOTCH1 | affects activity | ISO | Notch1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the activity of NOTCH1 protein | PMID:25585350 | NOTCH1 | affects expression | ISO | Notch1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of NOTCH1 mRNA | PMID:18343893 PMID:21570461 PMID:24058054 PMID:26377647 | NOTCH1 | affects expression | ISO | Notch1 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of NOTCH1 mRNA | PMID:34747641 | NOTCH1 | decreases expression | ISO | Notch1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of NOTCH1 mRNA | PMID:17586704 | NOTCH1 | increases expression | ISO | Notch1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of NOTCH1 mRNA | PMID:10886394 PMID:15328365 PMID:15800033 PMID:16611356 PMID:16960034 PMID:18796159 PMID:19684285 PMID:20702594 PMID:21889950 PMID:23994337 PMID:25975270 PMID:26290441 | NOTCH1 | increases expression | ISO | Notch1 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of NOTCH1 mRNA | PMID:33387578 | NOTCH1 | multiple interactions | ISO | Notch1 (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of NOTCH1 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOTCH1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of NOTCH1 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of NOTCH1 mRNA] | PMID:15667827 PMID:16214954 PMID:17942748 PMID:25975270 | | ||||||||||||||||||||||
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