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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737121
Species: Mus musculus
RGD Object: Gene
Symbol: Ccn5
Name: cellular communication network factor 5
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CCN5 mRNA

PMID:15034205, PMID:16054899, PMID:19933214
multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CCN5 mRNA], [Tetrachlorodibenzodioxin co-treated with EGF protein] results in increased expression of CCN5 mRNA, Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CCN5 mRNA]

PMID:16054899
decreases expressionISORGD:13514966480464CTDTetrachlorodibenzodioxin results in decreased expression of CCN5 mRNA

PMID:19619570
multiple interactionsISORGD:13514966480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CCN5 mRNA

PMID:19619570
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.