GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tlr4 | affects expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of TLR4 mRNA | PMID:21570461 | Tlr4 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of TLR4 mRNA | PMID:21093581 PMID:21653731 | Tlr4 | multiple interactions | EXP | | 6480464 | CTD | [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA; [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of IDO1 mRNA; [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of IDO2 mRNA; [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFB1 mRNA; [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFB3 mRNA; Fish Oils inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TLR4 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased activity of NFKB1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased activity of RELA protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of ITGAX protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL6 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein]; Tetrachlorodibenzodioxin promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased activity of NFKB2 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of ICAM1 protein] | PMID:21097750 PMID:21653731 | Tlr4 | affects expression | ISO | Tlr4 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of TLR4 mRNA | PMID:22298810 PMID:32109520 | Tlr4 | decreases expression | ISO | Tlr4 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of TLR4 mRNA | PMID:33387578 | | ||||||||||||||||||||||
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