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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736675
Species: Homo sapiens
RGD Object: Gene
Symbol: SQLE
Name: squalene epoxidase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SQLEaffects expressionISOSqle (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SQLE mRNAPMID:26377647 PMID:28922406
SQLEdecreases expressionISOSqle (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SQLE mRNAPMID:11752688 PMID:32109520 PMID:33387578 PMID:34747641
SQLEdecreases expressionISOSqle (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SQLE mRNAPMID:28238261
SQLEmultiple interactionsISOSqle (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SQLE mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SQLE mRNAPMID:17942748 PMID:28433925
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