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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736489
Species: Mus musculus
RGD Object: Gene
Symbol: Ccne1
Name: cyclin E1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccne1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CCNE1 mRNAPMID:21570461
Ccne1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CCNE1 mRNAPMID:16120747 PMID:18372398 PMID:27913140
Ccne1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CCNE1 mRNAPMID:19770486
Ccne1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1A protein]]] which results in decreased activity of CDK2 protein; [Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]] which results in decreased activity of CDK2 protein; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of CCNE1 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [CCNE1 protein binds to CDK2 protein]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1A protein]]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein]]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CCNE1 promoter]PMID:16636136 PMID:19654925 PMID:20637255 PMID:25975270
Ccne1affects expressionISOCcne1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of CCNE1 mRNAPMID:22298810
Ccne1decreases expressionISOCcne1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CCNE1 mRNAPMID:32109520 PMID:33387578
Ccne1increases expressionISOCCNE1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CCNE1 proteinPMID:27312872
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