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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736204
Species: Homo sapiens
RGD Object: Gene
Symbol: IRS2
Name: insulin receptor substrate 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IRS2affects expressionISOIrs2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of IRS2 mRNAPMID:22298810
IRS2affects expressionISOIrs2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of IRS2 mRNAPMID:21570461
IRS2decreases expressionISOIrs2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of IRS2 mRNAPMID:21215274
IRS2decreases phosphorylationISOIrs2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased phosphorylation of IRS2 proteinPMID:23639626
IRS2multiple interactionsISOIrs2 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS2 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA]PMID:16054899 PMID:28433925
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