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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735738
Species: Homo sapiens
RGD Object: Gene
Symbol: A2M
Name: alpha-2-macroglobulin
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
A2Maffects expressionISOA2m (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of A2M mRNAPMID:34747641
A2Mdecreases expressionISOA2m (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of A2M mRNAPMID:19770486 PMID:33956508
A2Mdecreases expressionISOA2m (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of A2M mRNAPMID:21215274 PMID:32109520 PMID:33387578
A2Mmultiple interactionsISOA2m (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PZP mRNAPMID:17942748
A2Mmultiple interactionsISOA2m (Rattus norvegicus)6480464CTDAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of A2M mRNA]PMID:21215274
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