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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735440
Species: Homo sapiens
RGD Object: Gene
Symbol: NFKBIA
Name: NFKB inhibitor alpha
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFKBIAincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of NFKBIA mRNAPMID:11007951 PMID:20106945 PMID:21632981 PMID:26238291
NFKBIAmultiple interactionsEXP 6480464CTDCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NFKBIA mRNA]PMID:11007951
NFKBIAaffects expressionISONfkbia (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of NFKBIA mRNAPMID:21570461
NFKBIAaffects expressionISONfkbia (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of NFKBIA mRNAPMID:34747641
NFKBIAincreases expressionISONfkbia (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of NFKBIA mRNA; Tetrachlorodibenzodioxin results in increased expression of NFKBIA proteinPMID:18172886 PMID:20159946
NFKBIAincreases expressionISONfkbia (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of NFKBIA mRNAPMID:33387578
NFKBIAmultiple interactionsISONfkbia (Rattus norvegicus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased degradation of NFKBIA proteinPMID:23583884
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