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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735279
Species: Homo sapiens
RGD Object: Gene
Symbol: RPS6
Name: ribosomal protein S6
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RPS6multiple interactionsEXP 6480464CTDTetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]PMID:11179685
RPS6affects expressionISORps6 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of RPS6 mRNAPMID:21570461
RPS6decreases expressionISORps6 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of RPS6 proteinPMID:16548065
RPS6decreases expressionISORps6 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of RPS6 mRNAPMID:15034205
RPS6decreases phosphorylationISORps6 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased phosphorylation of RPS6 proteinPMID:23639626
RPS6increases expressionISORps6 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of RPS6 mRNAPMID:33387578
RPS6multiple interactionsISORps6 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPS6 mRNAPMID:16214954
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