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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735270
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP7B1
Name: cytochrome P450 family 7 subfamily B member 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP7B1affects expressionISOCyp7b1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of CYP7B1 mRNAPMID:21570461 PMID:28922406
CYP7B1decreases expressionISOCyp7b1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP7B1 mRNAPMID:28213091 PMID:29452137
CYP7B1decreases expressionISOCyp7b1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP7B1 mRNAPMID:21215274 PMID:32109520
CYP7B1increases expressionISOCyp7b1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP7B1 mRNAPMID:34747641
CYP7B1multiple interactionsISOCyp7b1 (Mus musculus)6480464CTDAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP7B1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP7B1 gene]; Tetrachlorodibenzodioxin promotes the reaction [NFE2L2 gene mutant form results in decreased expression of CYP7B1 mRNA]PMID:21846477 PMID:28213091 PMID:29452137
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