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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735203
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbx3
Name: T-box transcription factor 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbx3affects expressionISOTBX3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of TBX3 mRNAPMID:22298810
Tbx3affects expressionISOTbx3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TBX3 mRNAPMID:21570461
Tbx3increases expressionISOTBX3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of TBX3 mRNAPMID:16697128 PMID:19692669 PMID:20106945 PMID:21632981 PMID:21802500 PMID:26238291
Tbx3increases expressionISOTbx3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TBX3 mRNAPMID:24058054
Tbx3multiple interactionsISOTbx3 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin affects the methylation of TBX3 enhancer] which results in decreased expression of TBX3 mRNAPMID:33017471
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