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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735151
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccr7
Name: C-C motif chemokine receptor 7
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccr7decreases expressionISOCcr7 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CCR7 mRNAPMID:20819909
Ccr7increases expressionISOCCR7 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CCR7 mRNAPMID:20106945 PMID:21632981
Ccr7increases expressionISOCcr7 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CCR7 mRNA; Tetrachlorodibenzodioxin results in increased expression of CCR7 proteinPMID:20211938 PMID:29673856
Ccr7multiple interactionsISOCCR7 (Homo sapiens)6480464CTD[Lipopolysaccharides co-treated with Tetrachlorodibenzodioxin] affects the expression of CCR7 proteinPMID:27783115
Ccr7multiple interactionsISOCcr7 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CCR7 gene]PMID:20819909
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