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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733453
Species: Homo sapiens
RGD Object: Gene
Symbol: FABP4
Name: fatty acid binding protein 4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FABP4affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of FABP4 mRNAPMID:22574217
FABP4decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of FABP4 mRNAPMID:20106945 PMID:22262711
FABP4decreases expressionISOFabp4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of FABP4 mRNAPMID:15591033 PMID:16054899 PMID:7537747
FABP4increases expressionISOFabp4 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of FABP4 mRNAPMID:16960034 PMID:34747641
FABP4increases expressionISOFabp4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of FABP4 mRNAPMID:16960034 PMID:17942748 PMID:19933214 PMID:22539624 PMID:23864506 PMID:28238261 PMID:29673856
FABP4multiple interactionsISOFabp4 (Mus musculus)6480464CTD[Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of FABP4 mRNA; [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; [Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of FABP4 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]PMID:16054899 PMID:30722647
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