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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732939
Species: Homo sapiens
RGD Object: Gene
Symbol: OTC
Name: ornithine transcarbamylase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
OTCmultiple interactionsEXP 6480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of OTC mRNAPMID:26159488
OTCaffects expressionISOOtc (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of OTC mRNAPMID:26377647
OTCaffects expressionISOOtc (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of OTC mRNAPMID:22298810
OTCdecreases expressionISOOtc (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of OTC mRNAPMID:16960034 PMID:38013089
OTCdecreases expressionISOOtc (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of OTC mRNAPMID:16960034 PMID:18796159 PMID:20959002 PMID:21215274 PMID:21724226
OTCmultiple interactionsISOOtc (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of and results in decreased activity of OTC proteinPMID:38013089
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