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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732685
Species: Mus musculus
RGD Object: Gene
Symbol: Acox1
Name: acyl-Coenzyme A oxidase 1, palmitoyl
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acox1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ACOX1 mRNAPMID:16214954 PMID:18796159
Acox1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ACOX1 mRNA; Tetrachlorodibenzodioxin results in increased expression of ACOX1 proteinPMID:10497882 PMID:23864506
Acox1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ACOX1 mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ACOX1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]PMID:10497882 PMID:16214954 PMID:28433925
Acox1decreases expressionISOAcox1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ACOX1 mRNAPMID:21215274 PMID:33387578
Acox1increases expressionISOACOX1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of ACOX1 mRNAPMID:12377990 PMID:15345368
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