GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp8b1 | decreases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of CYP8B1 mRNA | PMID:21846477 PMID:28213091 PMID:28922406 PMID:29452137 | Cyp8b1 | multiple interactions | EXP | | 6480464 | CTD | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of CYP8B1 mRNA; AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP8B1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP8B1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP8B1 gene] | PMID:21846477 PMID:25975270 PMID:28213091 PMID:29452137 | Cyp8b1 | decreases expression | ISO | Cyp8b1 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of CYP8B1 mRNA | PMID:21724226 | Cyp8b1 | decreases expression | ISO | CYP8B1 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of CYP8B1 mRNA | PMID:20106945 | | ||||||||||||||||||||||
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