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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731891
Species: Homo sapiens
RGD Object: Gene
Symbol: FDFT1
Name: farnesyl-diphosphate farnesyltransferase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FDFT1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of FDFT1 proteinPMID:31225620
FDFT1affects expressionISOFdft1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of FDFT1 mRNAPMID:28922406
FDFT1decreases expressionISOFdft1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of FDFT1 mRNAPMID:16960034 PMID:21215274 PMID:32109520
FDFT1decreases expressionISOFdft1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of FDFT1 mRNAPMID:28213091 PMID:28238261
FDFT1increases expressionISOFdft1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of FDFT1 mRNAPMID:19770486
FDFT1multiple interactionsISOFdft1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of FDFT1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FDFT1 gene]PMID:28213091 PMID:28433925
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