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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731890
Species: Mus musculus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin dependent kinase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CDK1 mRNAPMID:21570461 PMID:26377647
Cdk1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CDK1 mRNAPMID:15667827 PMID:17942748 PMID:21496263
Cdk1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDK1 mRNAPMID:17942748
Cdk1affects expressionISOCdk1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of CDK1 mRNAPMID:34747641
Cdk1decreases expressionISOCdk1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CDK1 mRNAPMID:33387578
Cdk1decreases expressionISOCDK1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CDK1 mRNAPMID:15056799 PMID:19901195 PMID:21802500
Cdk1increases expressionISOCDK1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CDK1 mRNAPMID:21496263
Cdk1increases phosphorylationISOCdk1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of CDK1 proteinPMID:23298284
Cdk1increases phosphorylationISOCDK1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of CDK1 proteinPMID:22266097
Cdk1multiple interactionsISOCDK1 (Homo sapiens)6480464CTDalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein]; Mifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein]; PGR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein]PMID:22266097
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