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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731337
Species: Homo sapiens
RGD Object: Gene
Symbol: USP2
Name: ubiquitin specific peptidase 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
USP2affects expressionISOUsp2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of USP2 mRNAPMID:22298810
USP2affects expressionISOUsp2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of USP2 mRNAPMID:21570461 PMID:26377647 PMID:28922406
USP2decreases expressionISOUsp2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of USP2 mRNAPMID:19490992 PMID:21215274 PMID:21724226
USP2increases expressionISOUsp2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of USP2 mRNAPMID:33387578
USP2increases expressionISOUsp2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of USP2 mRNAPMID:19465110 PMID:19770486
USP2multiple interactionsISOUsp2 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of USP2 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of USP2 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to USP2 promoter]PMID:17942748 PMID:19654925 PMID:28433925
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