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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731028
Species: Homo sapiens
RGD Object: Gene
Symbol: SGK1
Name: serum/glucocorticoid regulated kinase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SGK1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SGK1 mRNAPMID:20106945 PMID:21632981 PMID:26238291
SGK1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SGK1 mRNAPMID:12377990 PMID:19619570 PMID:29110037
SGK1multiple interactionsEXP 6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SGK1 mRNAPMID:19619570
SGK1affects expressionISOSgk1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of SGK1 mRNAPMID:22298810 PMID:34747641
SGK1affects expressionISOSgk1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SGK1 mRNAPMID:21570461
SGK1decreases expressionISOSgk1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SGK1 mRNAPMID:32109520
SGK1decreases expressionISOSgk1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SGK1 mRNAPMID:19770486 PMID:33956508
SGK1increases expressionISOSgk1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SGK1 mRNAPMID:21215274
SGK1increases expressionISOSgk1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SGK1 mRNAPMID:18691609
SGK1multiple interactionsISOSgk1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin affects the methylation of SGK1 intron] which results in decreased expression of SGK1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SGK1 mRNAPMID:25975270 PMID:33017471
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