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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730953
Species: Homo sapiens
RGD Object: Gene
Symbol: TGFB2
Name: transforming growth factor beta 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TGFB2decreases chemical synthesisEXP 6480464CTDTetrachlorodibenzodioxin results in decreased chemical synthesis of TGFB2 mRNAPMID:1447203
TGFB2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of TGFB2 mRNAPMID:1447203 PMID:19619570
TGFB2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of TGFB2 proteinPMID:9787404
TGFB2multiple interactionsEXP 6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TGFB2 mRNAPMID:19619570
TGFB2affects expressionISOTgfb2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of TGFB2 mRNAPMID:34747641
TGFB2affects expressionISOTgfb2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TGFB2 mRNAPMID:26377647
TGFB2decreases expressionISOTgfb2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of TGFB2 mRNAPMID:33387578
TGFB2decreases expressionISOTgfb2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of TGFB2 mRNA; Tetrachlorodibenzodioxin results in decreased expression of TGFB2 proteinPMID:17056225 PMID:19933214 PMID:21097750 PMID:21131560 PMID:24035824
TGFB2increases expressionISOTgfb2 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TGFB2 mRNAPMID:32109520
TGFB2increases expressionISOTgfb2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TGFB2 mRNAPMID:14728982 PMID:27562557
TGFB2multiple interactionsISOTgfb2 (Mus musculus)6480464CTDAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of TGFB2 mRNA]PMID:15034205
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