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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730918
Species: Mus musculus
RGD Object: Gene
Symbol: Adm
Name: adrenomedullin
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Admdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ADM mRNAPMID:19770486
Admmultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADM mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of ADM mRNAPMID:17942748 PMID:25975270
Admaffects expressionISOAdm (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of ADM mRNAPMID:34747641
Admincreases expressionISOAdm (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ADM mRNAPMID:33387578
Admincreases expressionISOADM (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of ADM mRNAPMID:20106945 PMID:21632981 PMID:26238291
Admmultiple interactionsISOADM (Homo sapiens)6480464CTDpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA]PMID:20064835
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