GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il18 | affects expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of IL18 mRNA | PMID:12167310 PMID:21570461 | Il18 | multiple interactions | EXP | | 6480464 | CTD | KL protein inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 mRNA]]; KL protein inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 protein]]; Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL18 protein] | PMID:29885354 | Il18 | affects expression | ISO | Il18 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of IL18 mRNA | PMID:22298810 | Il18 | affects expression | ISO | IL18 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of IL18 mRNA | PMID:22298810 | Il18 | decreases expression | ISO | Il18 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of IL18 mRNA | PMID:33387578 | Il18 | decreases expression | ISO | IL18 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of IL18 mRNA | PMID:16039398 | Il18 | increases expression | ISO | Il18 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of IL18 mRNA | PMID:20959002 PMID:21215274 PMID:34747641 | |
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