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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70970
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgcs1
Name: 3-hydroxy-3-methylglutaryl-CoA synthase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgcs1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of HMGCS1 mRNAPMID:32109520 PMID:33387578 PMID:34747641
Hmgcs1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of HMGCS1 mRNAPMID:26232522
Hmgcs1affects expressionISOHmgcs1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of HMGCS1 mRNAPMID:24680724
Hmgcs1decreases expressionISOHmgcs1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of HMGCS1 mRNAPMID:18295293 PMID:22977169 PMID:28922406
Hmgcs1decreases expressionISOHMGCS1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of HMGCS1 mRNAPMID:20106945 PMID:21632981 PMID:21998131
Hmgcs1multiple interactionsISOHmgcs1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of HMGCS1 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGCS1 mRNAPMID:17942748 PMID:28433925
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