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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs2
Name: insulin receptor substrate 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of IRS2 mRNA

PMID:22298810
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of IRS2 mRNA

PMID:21215274
decreases phosphorylationEXP 6480464CTDTetrachlorodibenzodioxin results in decreased phosphorylation of IRS2 protein

PMID:23639626
affects expressionISORGD:7362056480464CTDTetrachlorodibenzodioxin affects the expression of IRS2 mRNA

PMID:21570461
multiple interactionsISORGD:7362056480464CTD[Tetrachlorodibenzodioxin co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of IRS2 mRNA, Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IRS2 mRNA]

PMID:16054899, PMID:28433925
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.