GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdkn1b | decreases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of CDKN1B mRNA | PMID:33387578 | Cdkn1b | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of CDKN1B mRNA; Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein | PMID:14742689 PMID:20566336 PMID:23639626 PMID:34747641 | Cdkn1b | affects localization | ISO | Cdkn1b (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the localization of CDKN1B protein | PMID:20805476 | Cdkn1b | affects response to substance | ISO | Cdkn1b (Mus musculus) | 6480464 | CTD | CDKN1B protein affects the susceptibility to Tetrachlorodibenzodioxin | PMID:20805476 | Cdkn1b | increases expression | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein | PMID:15157999 | Cdkn1b | increases expression | ISO | Cdkn1b (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of CDKN1B mRNA; Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein | PMID:10398686 PMID:11804338 PMID:11879969 PMID:18227101 PMID:18691609 PMID:20486776 PMID:20805476 PMID:21995607 PMID:24013123 | Cdkn1b | multiple interactions | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDKN1B protein; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]; Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]; Mifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]; PGR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]; Tetrachlorodibenzodioxin results in decreased expression of and results in decreased activity of CDKN1B protein | PMID:15157999 PMID:22266097 PMID:9705214 | Cdkn1b | multiple interactions | ISO | Cdkn1b (Mus musculus) | 6480464 | CTD | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]; [Tetrachlorodibenzodioxin co-treated with EGF protein] results in increased expression of CDKN1B protein; [Tetrachlorodibenzodioxin co-treated with IGF1 protein] results in increased expression of CDKN1B protein; [Tetrachlorodibenzodioxin co-treated with SHH protein] results in increased expression of CDKN1B protein; [Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1B protein]]] which results in decreased activity of CDK2 protein; [Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]] which results in decreased activity of CDK2 protein; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of CDKN1B mRNA; AHR affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides affects the expression of CDKN1B protein]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CDKN1B mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CDKN1B protein alternative form]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1B protein]]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]] | PMID:12883080 PMID:20486776 PMID:20637255 PMID:21995607 PMID:24013123 PMID:25975270 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |