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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69023
Species: Mus musculus
RGD Object: Gene
Symbol: Fdps
Name: farnesyl diphosphate synthetase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fdpsaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of FDPS mRNAPMID:21570461 PMID:26377647
Fdpsmultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of FDPS mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of FDPS mRNAPMID:25975270 PMID:28433925
Fdpsaffects expressionISOFdps (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of FDPS mRNAPMID:34747641
Fdpsdecreases expressionISOFdps (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of FDPS mRNA; Tetrachlorodibenzodioxin results in decreased expression of SMIM31 mRNAPMID:16054898 PMID:32109520
Fdpsdecreases expressionISOFDPS (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of FDPS mRNA; Tetrachlorodibenzodioxin results in decreased expression of FDPS proteinPMID:20106945 PMID:21296121 PMID:31225620
Fdpsincreases expressionISOFdps (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of FDPS mRNAPMID:33387578
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