GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sigmar1 | affects expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of SIGMAR1 mRNA | PMID:21570461 | Sigmar1 | decreases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of SIGMAR1 mRNA | PMID:28213091 | Sigmar1 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of SIGMAR1 mRNA | PMID:17942748 | Sigmar1 | multiple interactions | EXP | | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SIGMAR1 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SIGMAR1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SIGMAR1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SIGMAR1 gene] | PMID:17942748 PMID:25975270 PMID:28213091 PMID:28433925 | Sigmar1 | affects expression | ISO | Sigmar1 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of SIGMAR1 mRNA | PMID:22298810 | Sigmar1 | decreases expression | ISO | Sigmar1 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of SIGMAR1 mRNA | PMID:34747641 | |
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