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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68520
Species: Mus musculus
RGD Object: Gene
Symbol: Sigmar1
Name: sigma non-opioid intracellular receptor 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sigmar1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of SIGMAR1 mRNAPMID:21570461
Sigmar1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SIGMAR1 mRNAPMID:28213091
Sigmar1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SIGMAR1 mRNAPMID:17942748
Sigmar1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SIGMAR1 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SIGMAR1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SIGMAR1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SIGMAR1 gene]PMID:17942748 PMID:25975270 PMID:28213091 PMID:28433925
Sigmar1affects expressionISOSigmar1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of SIGMAR1 mRNAPMID:22298810
Sigmar1decreases expressionISOSigmar1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SIGMAR1 mRNAPMID:34747641
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