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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68509
Species: Homo sapiens
RGD Object: Gene
Symbol: SULT1A2
Name: sulfotransferase family 1A member 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SULT1A2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SULT1A2 mRNAPMID:20106945 PMID:21632981
SULT1A2affects expressionISOSult1a1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SULT1A1 mRNAPMID:26377647
SULT1A2decreases expressionISOSult1a1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SULT1A1 mRNAPMID:19770486 PMID:26290441 PMID:28213091
SULT1A2multiple interactionsISOSult1a1 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of SULT1A1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SULT1A1 gene]PMID:25975270 PMID:28213091
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