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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67376
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sds
Name: serine dehydratase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SDS mRNA

PMID:20959002, PMID:21215274
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SDS mRNA

PMID:16054898
affects expressionISORGD:7340536480464CTDTetrachlorodibenzodioxin affects the expression of SDS mRNA

PMID:22298810
affects expressionISORGD:7340546480464CTDTetrachlorodibenzodioxin affects the expression of SDS mRNA

PMID:26377647
decreases expressionISORGD:7340536480464CTDTetrachlorodibenzodioxin results in decreased expression of SDS mRNA

PMID:20106945, PMID:26159488
decreases expressionISORGD:7340546480464CTDTetrachlorodibenzodioxin results in decreased expression of SDS mRNA

PMID:18172886, PMID:18796159, PMID:19770486
multiple interactionsISORGD:7340536480464CTDEndosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SDS mRNA], Tetrachlorodibenzodioxin inhibits the reaction [Endosulfan results in increased expression of SDS mRNA]

PMID:26159488
multiple interactionsISORGD:7340546480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of SDS mRNA, [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDS mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of SDS mRNA

PMID:16214954, PMID:17942748, PMID:25975270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.