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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628621
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gjd4
Name: gap junction protein, delta 4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gjd4decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of GJD4 mRNAPMID:32109520
Gjd4multiple interactionsISOGjd4 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of GJD4 genePMID:21212295
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