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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621703
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxc2
Name: forkhead box C2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxc2affects expressionISOFoxc2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of FOXC2 mRNAPMID:21570461
Foxc2decreases expressionISOFOXC2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of FOXC2 mRNAPMID:21296121
Foxc2decreases expressionISOFoxc2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of FOXC2 mRNAPMID:19933214
Foxc2increases expressionISOFoxc2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of FOXC2 mRNAPMID:24058054 PMID:26139165
Foxc2multiple interactionsISOFoxc2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the reaction [AHR protein binds to FOXC2 promoter]PMID:19654925
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