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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621464
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2az1
Name: H2A.Z variant histone 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2az1affects expressionISOH2az1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of H2AZ1 mRNAPMID:21570461 PMID:24680724
H2az1increases expressionISOH2az1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of H2AZ1 mRNAPMID:17942748 PMID:19465110
H2az1multiple interactionsISOH2az1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of H2AZ1 mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of H2AZ1 mRNA]PMID:17942748 PMID:19465110
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